TB treatment

WHO World TB Day 2019 campaign site

Each year, we commemorate World Tuberculosis (TB) Day on March 24 to raise public awareness about the devastating health, social and economic consequences of TB, and to step up efforts to end the global TB epidemic. The date marks the day in 1882 when Dr Robert Koch announced that he had discovered the bacterium that causes TB, which opened the way towards diagnosing and curing this disease.

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Transmission of drug-resistant tuberculosis in HIV-endemic settings

Author
Palwasha Y Khan, PhD; Tom A Yates, PhD; Muhammad Osman, MSc; Prof Robin M Warren, PhD; Yuri van der Heijden, MD; Nesri Padayatchi, PhD; et al.

The emergence and expansion of the multidrug-resistant tuberculosis epidemic is a threat to the global control of tuberculosis. Multidrug-resistant tuberculosis is the result of the selection of resistance-conferring mutations during inadequate antituberculosis treatment. However, HIV has a profound effect on the natural history of tuberculosis, manifesting in an increased rate of disease progression, leading to increased transmission and amplification of multidrug-resistant tuberculosis. Interventions specific to HIV-endemic areas are urgently needed to block tuberculosis transmission.

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The costs and outcomes of paediatric tuberculosis treatment at primary healthcare clinics in Johannesburg, South Africa

Author
Budgell EP, Evans D, Leuner R, Long L, Rosen S

Background: Little up-to-date information is available about the costs of providing drug-susceptible tuberculosis (DS-TB) treatment to paediatric patients in South Africa (SA), nor have actual costs incurred at clinics been compared with costs expected from guidelines.

Objective: To estimate actual and guideline treatment costs by means of a retrospective cohort analysis.

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Treatment initiation among persons diagnosed with drug resistant tuberculosis in Johannesburg, South Africa

Author
Denise Evans, Kathryn Schnippel, Caroline Govathson, Tembeka Sineke, Andrew Black, Lawrence Long, Rebecca Berhanu, Sydney Rosen
In South Africa, roughly half of the drug-resistant TB cases diagnosed are reported to have been started on treatment. We determined the proportion of persons diagnosed with rifampicin resistant (RR-) TB who initiated treatment in Johannesburg after the introduction of decentralized RR-TB care in 2011.
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It’s Time to Accelerate the TB Response

The first-ever UN high level meeting on tuberculosis (TB) on 26 September 2018 in New York was a crucial political moment for TB. It resulted in an endorsement of the first UN Political Declaration on TB [1], specifying prevention and treatment targets and commitments to mobilizing additional resources for the TB response, including research and development.

Author
Sharonann Lynch, HIV & TB Policy Advisor, Médecins Sans Frontières (MSF) Access Campaign
Source
Differentiated Service Delivery Blog

High rates of death and loss to follow-up by 12 months of rifampicin resistant TB treatment in South Africa

Author
Kamban Hirasen, Rebecca Berhanu, Denise Evans, Sydney Rosen, Ian Sanne, Lawrence Long
Treatment success rates of rifampicin resistant (RR)/multi-drug resistant (MDR) tuberculosis (TB) in South Africa range from 43–48%, falling short of the World Health Organization’s target of ≥75%. We present rates and assess predictors of attrition by 12 months on treatment.
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Associated factors with unsuccessful tuberculosis treatment outcomes among tuberculosis/HIV coinfected patients with drug-resistant tuberculosis

Author
Azeez, A., et al.

BACKGROUND: In Sub-Saharan Africa, HIV endemic has substantially contributed to the increasing tuberculosis (TB) incidence. The joint effect of the HIV and TB pestilences has confronted the feeble systems of healthcare in resource-limited countries.

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