TB prevention

WHO World TB Day 2019 campaign site

Each year, we commemorate World Tuberculosis (TB) Day on March 24 to raise public awareness about the devastating health, social and economic consequences of TB, and to step up efforts to end the global TB epidemic. The date marks the day in 1882 when Dr Robert Koch announced that he had discovered the bacterium that causes TB, which opened the way towards diagnosing and curing this disease.

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Transmission of drug-resistant tuberculosis in HIV-endemic settings

Author
Palwasha Y Khan, PhD; Tom A Yates, PhD; Muhammad Osman, MSc; Prof Robin M Warren, PhD; Yuri van der Heijden, MD; Nesri Padayatchi, PhD; et al.

The emergence and expansion of the multidrug-resistant tuberculosis epidemic is a threat to the global control of tuberculosis. Multidrug-resistant tuberculosis is the result of the selection of resistance-conferring mutations during inadequate antituberculosis treatment. However, HIV has a profound effect on the natural history of tuberculosis, manifesting in an increased rate of disease progression, leading to increased transmission and amplification of multidrug-resistant tuberculosis. Interventions specific to HIV-endemic areas are urgently needed to block tuberculosis transmission.

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Pocket Guide for Peer Education Program to Reduce TB and HIV Risks in Tanzania Prisons

Is the resource available on the Internet?
Yes
Author
Strengthening High Impact Interventions for an AIDS-free Generation (AIDSFree) Project

The objectives of this program are to encourage behavior change among inmates and prison staff to reduce the risk of HIV and tuberculosis (TB) by educating them about the contributing factors and encouraging use of available health services. This guide provides peer educators with activities and information necessary to deliver training on HIV and TB to inmates and prison staff. This guide contains six modules. Each module contains a brief introduction along with key facts and information.

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A score to predict and stratify risk of tuberculosis in adult contacts of tuberculosis index cases: a prospective derivation and external validation cohort study

Is the resource available on the Internet?
Yes
Author
Matthew J Saunders, Tom Wingfield, Marco A Tovar, Matthew R Baldwin, Sumona Datta, Karine Zevallos, Rosario Montoya, Teresa R Valencia, Jon S Friedland, Larry H Moulton, Robert H Gilman, Carlton A Evans

Contacts of tuberculosis index cases are at increased risk of developing tuberculosis. Screening, preventive therapy, and surveillance for tuberculosis are underused interventions in contacts, particularly adults. We developed a score to predict risk of tuberculosis in adult contacts of tuberculosis index cases.

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World TB Day collection

Is the resource available on the Internet?
Yes
Author
Elsevier

Although the number of deaths worldwide from tuberculosis—a disease caused by the bacterium Mycobacterium tuberculosis—fell by 22% between 2000 and 2015, it remains humanity’s biggest infectious killer and one of the top ten causes of all deaths. The 2016 WHO Global Tuberculosis Report estimated that in 2015 there were 10.4 million new tuberculosis cases and 1.4 million deaths. The interaction between tuberculosis and HIV is important, with an estimated 400 000 additional deaths occurring among people with co-infection.

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Beneficial Effect of Isoniazid Preventive Therapy and Antiretroviral Therapy on the Incidence of Tuberculosis in People Living with HIV in Ethiopia

Is the resource available on the Internet?
Yes
Author
Kesetebirhan Delele Yirdaw, Degu Jerene, Zewdu Gashu, M. E. Edginton, Ajay M. V. Kumar, Yohannes Letamo, Beniam Feleke, Alula M. Teklu, Solomon Zewdu, Bill Weiss, Andrea Ruff

Background

Isoniazid Preventive Therapy (IPT) with or without concomitant administration of ART is a proven intervention to prevent tuberculosis among PLHIV. However, there are few data on the routine implementation of this intervention and its effectiveness in settings with limited resources.

Objectives

To measure the level of uptake and effectiveness of IPT in reducing tuberculosis incidence in a cohort of PLHIV enrolled into HIV care between 2007 and 2010 in five hospitals in southern Ethiopia.

Methods

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