resource-limited settings

Prevalence of HIV infection among people with disabilities: a population-based observational study in Yaoundé, Cameroon (HandiVIH)

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Yes
Author
De Beaudrap, P., Beninguisse, G., Pasquier, E., et al.

In resource-limited settings, people with disabilities have been left behind in the response to HIV. In the HandiVIH study, we estimate and compare HIV prevalence and associated risk factors between people with and without disabilities.

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The virological durability of first-line ART among HIV-positive adult patients in resource limited settings without virological monitoring: a retrospective analysis of DART trial data

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Yes
Author
David I. Dolling, Ruth L. Goodall, Michael Chirara, James Hakim, Peter Nkurunziza, Paula Munderi, David Eram, Dinah Tumukunde, Moira J. Spyer, Charles F. Gilks, Pontiano Kaleebu, David T. Dunn, Deenan Pillay

Few low-income countries have virological monitoring widely available. We estimated the virological durability of first-line antiretroviral therapy (ART) after five years of follow-up among adult Ugandan and Zimbabwean patients in the DART study, in which virological assays were conducted retrospectively.

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Cost-effectiveness of CRAG-LFA screening for cryptococcal meningitis among people living with HIV in Uganda

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Yes
Author
Anu Ramachandran, Yukari Manabe, Radha Rajasingham and Maunank Shah

Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determine the cost-effectiveness of implementing CRAG screening using the recently developed CRAG lateral flow assay in Uganda compared to current practice without screening.

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Combatting Global Infectious Diseases: A Network Effect of Specimen Referral Systems

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Author
Peter N. Fonjungo George A. Alemnji Yenew Kebede Alex Opio Christina Mwangi Thomas J. Spira R. Suzanne Beard John N. Nkengasong

The recent Ebola virus outbreak in West Africa clearly demonstrated the critical role of laboratory systems and networks in responding to epidemics. Because of the huge challenges in establishing functional laboratories at all tiers of health systems in developing countries, strengthening specimen referral networks is critical. In this review article, we propose a platform strategy for developing specimen referral networks based on 2 models: centralized and decentralized laboratory specimen referral networks.

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Optimizing Infant HIV Diagnosis in Resource-Limited Settings: Modeling the Impact of HIV DNA PCR Testing at Birth

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Yes
Author
Chiu, Alexander MD; Modi, Surbhi MD, MPH; Rivadeneira, Emilia D. MD; Koumans, Emilia H. MD, MPH

Early antiretroviral therapy (ART) initiation in HIV-infected infants significantly improves survival but is often delayed in resource-limited settings. Adding HIV testing of infants at birth to the current recommendation of testing at age 4–6 weeks may improve testing rates and decrease time to ART initiation. We modeled the benefit of adding HIV testing at birth to the current 6-week testing algorithm.

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Development of tuberculosis infection control guidelines in a pediatric HIV clinic in sub-Saharan Africa

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Yes
Author
Carlucci, J. G.; Jin, L.; Sanders, J. E.; Mohapi, E. Q.; Mandalakas, A. M.

Setting: A well-established pediatric human immunodeficiency virus (HIV) clinic in Lesotho with initial infection control (IC) measures prioritizing blood-borne disease. In line with international recommendations, services have been expanded to include the management of patients with tuberculosis (TB). The creation of comprehensive IC guidelines with an emphasis on TB has become a priority.

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