pre-exposure prophylaxis (PrEP)

Topical Inserts: A Versatile Delivery Form for HIV Prevention

The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms. They may be used for vaginal and/or rectal administration of a variety of agents with antiviral activity. Topical inserts deliver drugs to the portal of viral entry, i.e., the genital or rectal mucosa, with low systemic exposure, and therefore are safer and have fewer side effects than systemic PrEP agents.

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There’s power in OPTIONS: Recent developments from the project that is optimizing HIV prevention technology introduction on schedule

“We know that life-changing HIV prevention solutions are available, but it’s critical to think strategically about how an innovation like PrEP is meaningful to our priority users. By understanding who our user is, what is important to them, and how PrEP can be positioned as useful and beneficial, we can help create an enabling environment for PrEP uptake.” - Briana Ferrigno, McCann Health

Author
Aubrey Weber, Technical Officer, FHI 360

PrEP4Youth video series

Oral pre-exposure prophylaxis (PrEP) is a new HIV prevention method that offers more than 90 percent protection when taken correctly. The OPTIONS Consortium, in collaboration with the South African National Department of Health, created five short, powerful videos that encourage PrEP as an acceptable HIV prevention method for adolescent girls and young women.

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HIV Prevention Ambassador toolkit

The HIV Prevention Ambassador toolkit includes colorful, 1-page handouts and worksheets in a booklet format that trained HIV Prevention Ambassadors can use to conduct peer support, community discussions, and other activities. The toolkit is designed to accompany the Ambassador Training Package and can be translated into local languages.

HIV Prevention Ambassador Training Package

The OPTIONS Consortium, in collaboration with Collective Action, has developed an HIV Prevention Ambassador Training Package to support adolescent girls and young women (AGYW) to play a meaningful role in the rollout of oral PrEP in their communities. Through interactive activities, discussion, and action planning, the training prepares Ambassadors to share information with their peers about oral PrEP as part of combination HIV prevention. Ambassadors also gain skills to support peers who are interested in using PrEP and to build community support for AGYW use of oral PrEP. For any Ambassadors who have not been previously trained on sexual and reproductive health and rights, the training also includes foundational sessions on sexual and reproductive health, human rights, gender, violence and HIV transmission.
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Evaluating the potential impact and cost-effectiveness of dapivirine vaginal ring pre-exposure prophylaxis for HIV prevention

This analysis offers a wide range of scenarios given the considerable uncertainty over ring uptake, consistency of use, and effectiveness, as well as HIV testing, prevention, and treatment use over the next two decades. This could help inform donors and implementers as they decide where to allocate resources in order to maximize the impact of the dapivirine ring in light of funding and implementation constraints.
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Scoring big with Grassroot Soccer at SA AIDS 2019

The biennial South African AIDS Conference (SA AIDS 2019), which took place earlier this month in Durban, South Africa, was an opportunity to meet a diverse range of players in the field of HIV and AIDS -- and one of the most innovative and inspiring of these is definitely Grassroot Soccer (GRS), so the SHARE team was really excited to get the chance to chat with some of the organization’s coaches, or young adult mentors, and master trainers about the work they are doing and what brought them to the conference.
Author
Aubrey Weber, Johanna Theunissen and Danya-Zee Pedra

Reaching at-risk women for PrEP delivery: What can we learn from clinical trials in sub-Saharan Africa?

ARV-based pre-exposure prophylaxis (PrEP) has the potential to avert many new HIV infections, yet little is known about how to reach women at high risk for HIV infection and motivate them to initiate PrEP. Clinical trials have succeeded in recruiting at-risk participants, evidenced by control arm HIV incidence ≥3% (defined by the World Health Organization as “substantial risk”). We examined experiences from HIV prevention trials to document recruitment strategies and identify practical, potentially effective strategies for reaching women in real-world PrEP delivery.
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How can programmes better support female sex workers to avoid HIV infection in Zimbabwe? A prevention cascade analysis

'HIV prevention cascades' have been proposed to support programmes by identifying gaps in demand for, access to and capability to adhere to HIV prevention tools, but there are few empirical examples to guide development. We apply a prevention cascade framework to examine prevention coverage and factors associated with condoms and/or PrEP adherence among female sex workers (FSW).
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Introducing “V”– An Innovative Approach to Increase PrEP Uptake and Adherence

USAID’s Office of HIV/AIDS (OHA) and the Center for Innovation and Impact (CII) are excited to announce the launch of “V”, a human-centered design approach to addressing challenges in uptake and adherence for oral PrEP among adolescent girls and young women. “V” is designed to combine innovations in product packaging — such as a starter kit to spark interest in oral PrEP initiation that includes a pill case designed to look like lip gloss — with private sector advertising and marketing approaches to encourage demand and reinforce adherence.

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