The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms. They may be used for vaginal and/or rectal administration of a variety of agents with antiviral activity. Topical inserts deliver drugs to the portal of viral entry, i.e., the genital or rectal mucosa, with low systemic exposure, and therefore are safer and have fewer side effects than systemic PrEP agents.
pre-exposure prophylaxis (PrEP)
There’s power in OPTIONS: Recent developments from the project that is optimizing HIV prevention technology introduction on schedule
“We know that life-changing HIV prevention solutions are available, but it’s critical to think strategically about how an innovation like PrEP is meaningful to our priority users. By understanding who our user is, what is important to them, and how PrEP can be positioned as useful and beneficial, we can help create an enabling environment for PrEP uptake.” - Briana Ferrigno, McCann Health
Oral pre-exposure prophylaxis (PrEP) is a new HIV prevention method that offers more than 90 percent protection when taken correctly. The OPTIONS Consortium, in collaboration with the South African National Department of Health, created five short, powerful videos that encourage PrEP as an acceptable HIV prevention method for adolescent girls and young women.
Evaluating the potential impact and cost-effectiveness of dapivirine vaginal ring pre-exposure prophylaxis for HIV prevention
Reaching at-risk women for PrEP delivery: What can we learn from clinical trials in sub-Saharan Africa?
How can programmes better support female sex workers to avoid HIV infection in Zimbabwe? A prevention cascade analysis
USAID’s Office of HIV/AIDS (OHA) and the Center for Innovation and Impact (CII) are excited to announce the launch of “V”, a human-centered design approach to addressing challenges in uptake and adherence for oral PrEP among adolescent girls and young women. “V” is designed to combine innovations in product packaging — such as a starter kit to spark interest in oral PrEP initiation that includes a pill case designed to look like lip gloss — with private sector advertising and marketing approaches to encourage demand and reinforce adherence.