HIV prevention

Engaging study participants in interpreting results: Lessons from the TRIO study in Kenya and South Africa

Women account for 56% of new HIV infections in sub-Saharan Africa. Multipurpose Prevention Technologies (MPTs) are promising interventions because they combine HIV prevention with a less stigmatizing indication, such as pregnancy. We conducted a study with three placebo-only MPT products in Kisumu, Kenya and Soshanguve, South Africa, to assess preferences for attributes of tablets, vaginal rings and injectable products for dual prevention of HIV and pregnancy (TRIO Study). Here, we present former TRIO participants' views on the study results.
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There’s power in OPTIONS: Recent developments from the project that is optimizing HIV prevention technology introduction on schedule

“We know that life-changing HIV prevention solutions are available, but it’s critical to think strategically about how an innovation like PrEP is meaningful to our priority users. By understanding who our user is, what is important to them, and how PrEP can be positioned as useful and beneficial, we can help create an enabling environment for PrEP uptake.” - Briana Ferrigno, McCann Health

Author
Aubrey Weber, Technical Officer, FHI 360

PrEP4Youth video series

Oral pre-exposure prophylaxis (PrEP) is a new HIV prevention method that offers more than 90 percent protection when taken correctly. The OPTIONS Consortium, in collaboration with the South African National Department of Health, created five short, powerful videos that encourage PrEP as an acceptable HIV prevention method for adolescent girls and young women.

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Reaching at-risk women for PrEP delivery: What can we learn from clinical trials in sub-Saharan Africa?

ARV-based pre-exposure prophylaxis (PrEP) has the potential to avert many new HIV infections, yet little is known about how to reach women at high risk for HIV infection and motivate them to initiate PrEP. Clinical trials have succeeded in recruiting at-risk participants, evidenced by control arm HIV incidence ≥3% (defined by the World Health Organization as “substantial risk”). We examined experiences from HIV prevention trials to document recruitment strategies and identify practical, potentially effective strategies for reaching women in real-world PrEP delivery.
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9th SA AIDS Conference 2019

The 9th South African AIDS Conference took place from 11-14 June 2019 in Durban, South Africa, and the SHARE team was there to bring you updates, related content, and live coverage! The Conference focused on unprecedented scientific, social and digital innovations and technologies which could expand possibilities and opportunities towards controlling the HIV and AIDS epidemic. It also aimed to determine how contemporary explosive and disruptive technologies can contribute towards sustained HIV prevention efforts, HIV testing, ART uptake and adherence, trigger the development of new drugs, effectively utilise enormous volumes of data, and improve communication and service delivery, and eventually end the epidemic. Browse our dedicated SA AIDS 2019 page here.
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Test-And-Prevent Analysis: Key findings

Significant resources have created strong ‘test and treat’ programs globally. What about those who test HIV negative? How can we strengthen linkage of HIV-negative individuals to prevention programs in ways that work for them? In our recently completed Test-And-Prevent Analysis, the OPTIONS Consortium identifies practices for linking individuals from HIV testing to HIV prevention. This work aims to identify interventions that are effective, the enabling conditions that support linkage, and remaining questions.

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Potential role of regulatory T cells in mother-to-child transmission of HIV

BACKGROUND: Mother-to-child transmission of HIV-1 occurs in a minority of HIV-infected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the fetus as well as in mother-to-child transmission of HIV is under-studied.

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Conference on Retroviruses and Opportunistic Infections (CROI 2019)

Venue
Seattle, Washington, USA

The annual Conference on Retroviruses and Opportunistic Infections (CROI) brings together top basic, translational, and clinical researchers from around the world to share the latest studies, important developments, and best research methods in the ongoing battle against HIV/AIDS and related infectious diseases. CROI 2019 will be held from March 4 to March 7, 2019, at the Washington State Convention Center in Seattle, Washington.

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