drug susceptibility testing (DST)

Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study

Author
Kathrin Zürcher, Marie Ballif, Prof Lukas Fenner, Sonia Borrell, Peter M Keller, Joachim Gnokoro et al.
Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory.
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WHO recommendations on shorter treatment of multidrug-resistant tuberculosis

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Author
Giovanni Sotgiu, Simon Tiberi, Lia D'Ambrosio, Rosella Centis, Alimuddin Zumla, Giovanni Battista Migliori

Tuberculosis is now the world's commonest cause of death from infectious disease. The ominous spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis, and the scarce treatment options available, are priority global health issues. With a global estimate in 2014 of 450 000 cases of MDR and XDR tuberculosis causing 150 000 deaths, and the continuing spread, the WHO End TB Strategy highlights the threat that MDR and XDR tuberculosis pose to global public health security.

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