drug resistance

Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study

Author
Kathrin Zürcher, Marie Ballif, Prof Lukas Fenner, Sonia Borrell, Peter M Keller, Joachim Gnokoro et al.
Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory.
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High rates of death and loss to follow-up by 12 months of rifampicin resistant TB treatment in South Africa

Author
Kamban Hirasen, Rebecca Berhanu, Denise Evans, Sydney Rosen, Ian Sanne, Lawrence Long
Treatment success rates of rifampicin resistant (RR)/multi-drug resistant (MDR) tuberculosis (TB) in South Africa range from 43–48%, falling short of the World Health Organization’s target of ≥75%. We present rates and assess predictors of attrition by 12 months on treatment.
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4th Southern African HIV Clinicians Society Conference

The Southern African HIV Clinicians Society’s biannual conference, held in Johannesburg, South Africa, from 24-27 October 2018, focused on clinical content for HIV and TB health care workers in the region and featured a wide range of topics, from new antiretroviral drugs, AIDS-related complications, and opportunistic infections, to promoting adherence and ethical issues.

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Call for Abstracts: 4th Southern African HIV Clinicians Society Conference

Closing date

The Southern African HIV Clinicians Society’s biannual conference focuses on clinical content for HIV and TB health care workers. The 2018 conference programme has been carefully designed to benefit all health care practitioners, with topics ranging from new antiretroviral drugs, AIDS-related complications, opportunistic infections, promoting adherence and ethical issues.

The fourth HIV epidemic

In The Lancet Infectious Diseases, Ravindra Gupta and colleagues1 present alarming results on the development of pre-treatment viral resistance to the most commonly used drugs to treat HIV infection in resource-limited countries. These findings complete the bleak picture of antiretroviral (ARV) treatment failure that is gradually emerging in these countries.

Author
Gabrièle Laborde-Balen, Bernard Taverne, Cheikh Tidiane Ndour, Charles Kouanfack, Martine Peeters, Ibra Ndoye, Eric Delaporte
Source
The Lancet Infectious Diseases

Why Finding New HIV Targets Takes So Long: Some Basics About Basic Research

Although great strides have been made at combating human immunodeficiency virus, leading to better quality of life and a longer life expectancy for those living with the virus, significant problems remain.

Author
Christy Gaines
Source
TheBodyPRO.com

HIV-1 viraemia and drug resistance amongst female sex workers in Soweto, South Africa: A cross sectional study

Is the resource available on the Internet?
Yes
Author
Coetzee J, Hunt G, Jaffer M, Otwombe K, Scott L, Bongwe A, Ledwaba J, Molema S, Jewkes R, Gray GE

HIV drug resistance (HIVDR) poses a threat to future antiretroviral therapy success. Monitoring HIVDR patterns is of particular importance in populations such as sex workers (SWs), where documented HIV prevalence is between 34-89%, and in countries with limited therapeutic options. Currently in South Africa, there is a dearth in evidence and no ongoing surveillance of HIVDR amongst sex work populations. This study aims to describe the prevalence of HIVDR amongst a sample of female sex workers (FSWs) from Soweto, South Africa.

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