co-trimoxazole

Effect of co-trimoxazole on mortality in HIV-exposed but uninfected children in Botswana (the Mpepu Study): a double-blind, randomised, placebo-controlled trial

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Yes
Author
Lockman, Shahin et al.

Background

Co-trimoxazole prophylaxis reduces mortality among HIV-infected children, but efficacy in HIV-exposed but uninfected (HEU) children in a non-malarial, low-breastfeeding setting with a low risk of mother-to-child transmission of HIV is unclear.

Methods

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Protective efficacy of prolonged co-trimoxazole prophylaxis in HIV-exposed children up to age 4 years for the prevention of malaria in Uganda: a randomised controlled open-label trial

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Yes
Author
Dr Jaco Homsy, Grant Dorsey, Emmanuel Arinaitwe, Humphrey Wanzira, Abel Kakuru, Victor Bigira, Mary Muhindo, Prof Moses R Kamya, Taylor G Sandison, Jordan W Tappero

WHO recommends daily co-trimoxazole for children born to HIV-infected mothers from 6 weeks of age until breastfeeding cessation and exclusion of HIV infection. We have previously reported on the effectiveness of continuation of co-trimoxazole prophylaxis up to age 2 years in these children. We assessed the protective efficacy and safety of prolonging co-trimoxazole prophylaxis until age 4 years in HIV-exposed children.

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Pilot Co-trimoxazole Tools Assessment

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Yes
Author
AIDSTAR-One

AIDSTAR-One developed and piloted provider and patient educational tools to increase appropriate prescription and use of co-trimoxazole for eligible people living with HIV. Before and after the pilot, AIDSTAR-One conducted a mixed-methods assessment to analyze the effectiveness and acceptability of the co-trimoxazole tools. This report recommends adoption and scale-up of the tools in Uganda and other countries.

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Co-trimoxazole Management and Availability Technical Report

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Yes
Author
AIDSTAR-One

With the scale-up of HIV treatment programs, substantial funding has been committed to guarantee an uninterrupted supply of co-trimoxazole for persons living with HIV (PLHIV), but access to this key intervention remains inconsistent. This technical report provides a summary of key challenges and innovations arising from 15 countries.

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