CD4 cell count

An Evaluation to Determine the Strongest CD4 Count Covariates during HIV Disease Progression in Women in South Africa

Past endeavours to deal with the obstacle of expensive Cluster of Difference 4 (CD4(+)) count diagnostics in resource-limited settings have left a long trail of suggested continuous CD4(+) count clinical covariates that turned out to be a potentially important integral part of the human immunodeficiency virus (HIV) treatment process during disease progression. However, an evaluation to determine the strongest candidates among these CD4(+) count covariates has not been well documented.
Include in home page features rotation
Off

'Good health' as a barrier and facilitator to ART initiation: a qualitative study in the era of test-and-treat in Mozambique

HIV test-and-treat programmes are being implemented throughout sub-Saharan Africa, enrolling HIV-positive clients into antiretroviral treatment (ART) immediately after diagnosis, regardless of clinical stage or CD4 count. This study conducted in Mozambique examined what influenced clients who tested HIV-positive in the context of test-and-treat to make ART initiation decisions.
Include in home page features rotation
Off

Global Trends in CD4 Cell Count at the Start of Antiretroviral Therapy: Collaborative Study of Treatment Programs

Is the resource available on the Internet?
Yes
Author
The IeDEA and COHERE Cohort Collaborations

Background

Early initiation of combination antiretroviral therapy (cART), at higher CD4 cell counts, prevents disease progression and reduces sexual transmission of human immunodeficiency virus (HIV). We describe the temporal trends in CD4 cell counts at the start of cART in adults from low-income, lower-middle-income, upper-middle-income, and high-income countries (LICs, LMICs, UMICs, and HICs, respectively).

Methods

Include in home page features rotation
Off

Determinants of time from HIV infection to linkage-to-care in rural KwaZulu-Natal, South Africa

Is the resource available on the Internet?
Yes
Author
Maheu-Giroux, Mathieu; Tanser, Frank; Boily, Marie-Claude; Pillay, Deenan; Joseph, Serene A.; Bärnighausen, Till

Objective: To estimate time from HIV infection to linkage-to-care and its determinants. Linkage-to-care is usually assessed using the date of HIV diagnosis as the starting point for exposure time. However, timing of diagnosis is likely endogenous to linkage, leading to bias in linkage estimation.

Include in home page features rotation
Off

Impact of Age and Sex on CD4+ Cell Count Trajectories following Treatment Initiation: An Analysis of the Tanzanian HIV Treatment Database

Is the resource available on the Internet?
Yes
Author
Arianna R. Means, Kathryn A. Risher, Eva L. Ujeneza, Innocent Maposa, Joseph Nondi, Steven E. Bellan

New guidelines recommend that all HIV-infected individuals initiate antiretroviral treatment (ART) immediately following diagnosis. This study describes how immune reconstitution varies by gender and age to help identify poorly reconstituting subgroups and inform targeted testing initiatives.

Include in home page features rotation
Off

When Does HIV Become AIDS?

Is the resource available on the Internet?
Yes
Author
Sally Robertson

The HIV virus infects and destroys CD4 positive (CD4+) cells, a type of immune cell that plays a key role in maintaining the human immune system and fighting off disease.

Also called T-helper cells, CD4+ cells are responsible for instructing other cells of the immune system to perform their specific functions. At the time of infection with HIV, the higher the number of CD4+ cells that become damaged, the weaker the immune system becomes and the less able a person is to fight off infection and disease. Eventually, this results in the development of AIDS.

Include in home page features rotation
Off

POC CD4 Testing Improves Linkage to HIV Care and Timeliness of ART Initiation in a Public Health Approach: A Systematic Review and Meta-Analysis

Is the resource available on the Internet?
Yes
Author
Lara Vojnov, Jessica Markby, Caroline Boeke, Lindsay Harris, Nathan Ford and Trevor Peter

CD4 cell count is an important test in HIV programs for baseline risk assessment, monitoring of ART where viral load is not available, and, in many settings, antiretroviral therapy (ART) initiation decisions. However, access to CD4 testing is limited, in part due to the centralized conventional laboratory network. Point of care (POC) CD4 testing has the potential to address some of the challenges of centralized CD4 testing and delays in delivery of timely testing and ART initiation.

Include in home page features rotation
Off

Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study

Is the resource available on the Internet?
Yes
Author
The TenoRes Study Group

Background

Antiretroviral therapy (ART) is crucial for controlling HIV-1 infection through wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir disoproxil fumarate-containing regimens are increasingly used to treat and prevent HIV, although few data exist for frequency and risk factors of acquired drug resistance in regions hardest hit by the HIV pandemic. We aimed to do a global assessment of drug resistance after virological failure with first-line tenofovir-containing ART.

Include in home page features rotation
Off
Subscribe to CD4 cell count