Transmission of Extensively Drug-Resistant Tuberculosis in South Africa

N. Sarita Shah et al.

South Africa has one of the highest burdens of tuberculosis and drug-resistant tuberculosis in the world. In the past decade, the number of cases of XDR tuberculosis has increased by a factor of 10, to more than 1500 cases in 2012. Compounding the tuberculosis epidemic is the concurrent epidemic of HIV infection; rates of coinfection exceed 70%, and rates of long-term survival among patients with XDR tuberculosis and HIV infection are less than 20%. In this study, we sought to quantify the role of transmission and to elucidate how and where transmission is occurring. We combined traditional epidemiologic tools with social-network, geospatial, and genotyping methods to describe population-level transmission of XDR tuberculosis.

January 24, 2017
Year of publication
2017
Resource types
Journal and research articles
Tags
South Africa, tuberculosis, TB, drug-resistant TB, co-infection, HIV-TB co-infection, extensively drug-resistant TB (XDR-TB), TB transmission

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BACKGROUND:

Attrition along the HIV care continuum slows gains in mitigating the South African HIV epidemic. Understanding population-level gaps in HIV identification, linkage, retention in care and viral suppression is critical to target programming.