Building on the current progress, additional and continuous steps must be taken to ensure the sustainability of the HIV response; the tremendous gains of the past three decades are in danger of being lost as the window of opportunity to control the epidemic snaps closed. PEPFAR has responded to this imperative by hardwiring sustainability into its business practices and expecting partner countries to commit to sustainability investments and meaningfully engage communities and civil society in their HIV response. In partnership with national HIV responses and others, PEPFAR programs are urgently taking immediate, near-term and longer-term critical actions to ensure that the right enabling environment, systems, services, and resources are in place to sustainably control the HIV epidemic. Progress is being continuously tracked and measured. With a clear focus on building sustainability into national HIV responses, the HIV epidemic can be controlled. We will achieve an AIDS-free generation and ensure effective systems are available for control of all future pandemics and chronic diseases.