With new prevention strategies on the horizon and HIV incidence stabilizing or declining in many parts of the world, the tides are beginning to turn on the HIV epidemic. Between 2002 and 2010, new HIV infections globally declined from 3.1 million to 2.7 million. However, 33.3 million people globally are still estimated to be living with HIV, including 2.5 million children. Approximately 40 percent of all women living with HIV are in sub-Saharan Africa. This technical brief discusses barriers to and outlines current and developing strategies to scale up traditionally vertical programs that work towards achieving the millennium development goals that focus on maternal, newborn and child health, HIV and AIDS, and malaria.