HIV-1 is undetectable in preejaculatory secretions from HIV-1-infected men on suppressive HAART

Politch, Joseph A.; Mayer, Kenneth H.; Anderson, Deborah J.

Preejaculatory fluid, a viscous, lubricating secretion expressed by penile urethral glands during sexual excitement, may play a role in the sexual transmission of HIV-1. The urethra has been shown to be an important site of HIV infection in men and male macaques, and preejaculatory fluid and urethral swabs from HIV-1-infected men often contain HIV. Recent studies have shown that HAART reduces but does not eliminate seminal HIV shedding in infected men, and that the penile urethra remains a site of persistent simian immunodeficiency virus infection in HAART-treated macaques. The objective of this study was to determine whether HIV-infected men on stable HAART continue to shed HIV into preejaculatory secretions.

August 29, 2016
Year of publication
Resource types
Journal and research articles, Reports and Fact sheets
preejaculatory fluid, preejaculatory secretions, sexual transmission, HIV infection, highly active antiretroviral therapy (HAART), HAART, seminal HIV shedding

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