False-negative HIV tests using oral fluid tests in children taking antiretroviral therapy from Harare, Zimbabwe

Ioana D. Olaru, Grace McHugh, Suba Dakshina, Edith Majonga, Ethel Dauya, Tsitsi Bandason, Katharina Kranzer, Hilda Mujuru, Rashida Ferrand

Rapid diagnostic tests (RDT) for HIV infection have high sensitivity and specificity, but in the setting of longstanding antiretroviral therapy (ART), can give false results that can lead to misinterpretation, confusion and inadequate management. The objective of this study was to evaluate the proportion of falsely negative results of a RDT performed on oral fluid in HIV-infected children on longstanding ART.

This study found that a substantial proportion of false-negative HIV test results in children on longstanding ART when using an oral fluid test. This could lead to misinterpretation of HIV test results and in the false perception of cure or delayed diagnosis.

August 31, 2017
Year of publication
2017
Resource types
Journal and research articles
Countries
Tags
oral fluid tests, children, Zimbabwe, false negative, rapid diagnostic tests (RDTs), antiretroviral therapy (ART), ART, longstanding ART, treatment, HIV misdiagnosis, misdiagnosis, misinterpretation, HIV-infected children

Similar Resources

To understand the uptake of HIV services by adolescent women, the authors conducted a retrospective analysis of patient-level data (2011–2013) on services for antenatal care (ANC) and prevention of mother-to-child transmission (PMTCT) in 36 facilities in 5 districts in Zimbabwe.

Female sex workers (FSW) in sub-Saharan Africa have a higher prevalence of HIV than other women of reproductive age. Social, legal, and structural barriers influence their access to care. Little is known about the HIV diagnosis and care cascade in most countries in southern Africa.

In view of expanding 'test and treat' initiatives, we sought to elicit how the experience of HIV testing influenced subsequent engagement in HIV care among people diagnosed with HIV.

Rapid diagnostic tests (RDTs) are the primary diagnostic tools for HIV used in resource-constrained settings.

Children living with HIV who are not diagnosed in infancy often remain undiagnosed until they present with advanced disease.

The AIDSFree HIV Testing Services (HTS) Guidance Database has been updated with new guidelines from many PEPFAR priority countries.

Providing HIV testing at health facilities remains the most common approach to ensuring access to HIV treatment and prevention services for the millions of undiagnosed HIV-infected individuals in sub-Saharan Africa.

BACKGROUND: WHO recommends that HIV infected women receive antiretroviral therapy (ART) minimally during pregnancy and breastfeeding ("Option B"), or ideally throughout their lives regardless of clinical stage ("Option B+") (Coovadia et al., Lancet 379:221-228, 2012).

Adolescents newly diagnosed with HIV need to be rapidly incorporated into HIV care networks to have the best chances of remaining in care in the long term, research from the United States published in the June 1st edition of the Journal of Acquired Immune Deficiency Syndromes shows.