Does maternal HSV-2 co-infection increase mother-to-child transmission of HIV? A systematic review

Vishalini Sivarajah, Kevin Venus, Mark H Yudin, Kellie E Murphy, Steven A Morrison, Darrell HS Tan

Reducing HIV mother-to-child transmission (MTCT) is critical to ending the HIV pandemic. Reports suggest that herpes simplex virus-2 (HSV-2), a common coinfection in HIV-infected individuals, is associated with increased MTCT, but results have been conflicting. We conducted a systematic review of observational studies to quantify the magnitude of this relationship 

June 19, 2017
Year of publication
Resource types
Journal and research articles
mother-to-child transmission (MTCT), PMTCT, prevention of mother-to-child transmission (PMTCT), co-infection, HSV-2, herpes simplex virus-2 (HSV-2), HIV prevention