The burden of HIV: insights from the GBD 2010.

Ortblad KF, Lozano R, Murray CJ.

OBJECTIVES: To evaluate the global and country-level burden of HIV/AIDS relative to 291 other causes of disease burden from 1980-2010 using the Global Burden of Disease Study 2010 (GBD 2010) as the vehicle for exploration.

METHODS:: HIV/AIDS burden estimates were derived elsewhere as part of GBD 2010, a comprehensive assessment of the magnitude of 291 diseases and injuries from 1990 to 2010 for 187 countries. In GBD 2010, disability-adjusted life years (DALYs) are used as the measurement of disease burden. DALY estimates for HIV/AIDS come from UNAIDS' 2012 prevalence and mortality estimates, GBD 2010 disability weights, and mortality estimates derived from quality vital registration data.

RESULTS:: Despite recent declines in global HIV/AIDS mortality, HIV/AIDS was still the fifth leading cause of global DALYs in 2010.The distribution of HIV/AIDS burden is not equal across demographics and regions. In 2010, HIV/AIDS ranked as the leading DALY cause for ages 30 to 44 in both sexes and for 21 countries that fall into four distinctive blocks: Eastern and Southern Africa, Central Africa, the Caribbean, and Thailand. While a majority of the DALYs caused by HIV/AIDS are in high-burden countries, 20% of the global HIV/AIDS burden in 2010 was in countries where HIV/AIDS did not make the top 10 leading causes of burden.

CONCLUSIONS:: In the midst of a global economic recession, tracking the magnitude of the HIV/AIDS epidemic and its importance relative to other diseases and injuries is critical to effectively allocating limited resources and maintaining funding for effective HIV/AIDS interventions and treatments

September 12, 2013
Tags
HIV, AIDS, disease burden, Global Burden of Disease (GBD), disability-adjusted life years (DALYs), resource-limited settings, HIV Funding, treatment, HIV intervention

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