The purpose of this guide is to provide a resource for clinicians on the ground who manage HIV and TB clients on a daily basis. The guide presents the tools and knowledge required to ensure that clients are offered the best quality of service, and will also enable the health facility to move towards achieving the 90-90-90 targets. This guide does not replace any national policies or guidelines, but is intended to assist with translating policy into practice. The guide explains the origin of the 90-90-90 strategy, and offers step-by-step guidance on the management of TB and HIV clients, according to the prescribed treatment guidelines and algorithms covered in national policies. The guide also provides information on linkages to care, and on data collection to provide information for better planning and management of the HIV and TB programmes. The guide, which is also suitable for use in the private sector, follows the programmatic cascades of managing clients towards achieving 90-90-90 outcomes.