Resource Library

BACKGROUND: A universal testing and treatment strategy is a potential approach to reduce the incidence of human immunodeficiency virus (HIV)…

BACKGROUND: The NEVEREST-3 (South Africa) and MONOD-ANRS-12206 (Cote d'Ivoire, Burkina Faso) randomized trials found that switching to efavirenz (…

INTRODUCTION: HIV testing male partners of pregnant and postpartum women can lead to improved health outcomes for women, partners and infants.…

INTRODUCTION: Tuberculosis (TB) continues to be a leading cause of death in Sub-Saharan Africa, including Mozambique. While diagnostic methods and…

BACKGROUND: Little is known about contextual factors that predict long-term mortality following HIV testing in resource-limited settings. We…

There is increasing interest in home-based testing and treatment of HIV to expand access to treatment in sub-Saharan Africa. Such programs rely on self-reported HIV history and use of antiretroviral therapy (ART). However, the accuracy…

One-C is a community-based program that seeks to increase utilization of HIV services, improve linkages to services at the community level, and encourage the adoption of HIV risk reduction behaviors. Find out about the quantitative and qualitative results emerging from SOAR’s…

From January 2016 to December 2018, AIDSFree Lesotho provided technical assistance to two civil society organizations: the Lesotho Network of AIDS Service Organizations and the Lesotho Network of People Living with HIV and AIDS. In 2018, the project extended its services to two other…

Increasing numbers of people living with HIV (PLHIV) in sub-Saharan Africa are experiencing failure of first-line antiretroviral therapy and transitioning onto second-line regimens. However, there is a dearth of research on their treatment experiences. We conducted in-…

BACKGROUND: The focus of the community anti-retroviral therapy group model is on drug refill, adherence and support groups. However, laboratory services are completely neglected in this model, and stable patient still have to go to the clinic…

The impact and efficiency of HIV testing services can be further improved by targeting testing in networks of PLHIV who are not yet virally suppressed. This new project brief from the LINKAGES projects provides clear and concise…

Hear Dr. Vincent Tukei of Elizabeth Glaser Pediatric AIDS Foundation discuss SOAR findings on adverse pregnancy outcomes among HIV-positive women in Lesotho during an interview with…

SOAR researchers assessed a community-based program that provided female sex workers with mobile or home-based ART services. The findings demonstrate that the community-based model can lead to higher ART initiation and retention rates, and better adherence compared to standard…

Broadly neutralizing antibodies (bnAbs) are currently under investigation as a therapy for HIV-1 infection and recent clinical trials have shown prolonged viral suppression by bnAbs during antiretroviral treatment interruption. Interestingly, these bnAbs also showed the ability to activate the…

Background: HIV acquisition remains high among adolescent girls and young women (AGYW, aged 15–24 years) in sub-Saharan Africa. We aimed to estimate prevalence and incidence of HIV in AGYW and to identify correlates of HIV infection by using data from the Lesotho Population-…

Training Curriculum for Adolescent Girls and Young Women

The OPTIONS Consortium, in collaboration with Collective Action, has developed an HIV Prevention Ambassador…

mothers2mothers (m2m) is an African NGO working towards the Global Goals of ensuring good health for all and ending the AIDS epidemic by 2030. The organization focuses on three core client groups—women, children, and adolescents—serving those living with HIV, and also those who are HIV-negative…

With only a year until 2020 – and the deadline to reach the 90-90-90 targets – South Africa is dangerously off track. Currently 7.1 million people are living with HIV in the country. New HIV infections remain high, according to the Thembisa model1 at 275 000 in 2017, higher than the 231 000…

More adolescents and young adults living with HIV are surviving into adulthood. As a result they must transition from pediatric health services to HIV self-management and adult care. This change is particularly important as many young people have poor adherence to treatment, leading to low rates…

This research report documents the multiple benefits of meaningful youth participation and leadership in sexual health and rights (SRHR) programs. It synthesizes global evidence from the field on how to foster authentic youth engagement, the impacts that result, and recommendations that can…

The USAID/TSP HIV Child and Adolescent ARV Procurement Forecasting Tool is intended to assist program managers, clinicians and support staff in quantifying and budgeting for a program’s child and adolescent ARV needs. The tool…

Community health workers, community-based care, and community outreach have long been recognized as essential to extending the reach of facility-based health care systems. In South Africa there is limited information about what services are available, where they are available, eligibility…

Background: The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared with the evidence available for transmission risk in…

RATIONALE: In the context of rapid antiretroviral therapy (ART) rollout and an increasing burden of non-communicable diseases, there are few contemporary data describing the aetiology and outcome of community-acquired pneumonia (CAP) in sub-Saharan Africa.

BACKGROUND: Community-based GeneXpert MTB/RIF testing may increase detection of prevalent TB in the community and improve rates of TB treatment completion.

METHODS: We conducted a pilot randomized trial to evaluate the impact of GeneXpert screening on a…

BACKGROUND: The tolerance of antiretroviral drugs in infants must be carefully evaluated. In previous studies of children with HIV type 1 (HIV-1) less weight gain was observed in children given lopinavir-ritonavir-based combinations than those given nevirapine. We aimed to compare the effects of…

Increasing numbers of people living with HIV (PLHIV) in sub-Saharan Africa are experiencing failure of first-line antiretroviral therapy and transitioning onto second-line regimens. However, there is a dearth of research on their treatment experiences. We conducted in-depth interviews with 43…

OBJECTIVE: To examine the prevalence and magnitude of chronic lung disease (CLD) and its association with empiric anti-tuberculosis treatment (due to lack of bacteriologic confirmation) among recurrent tuberculosis (TB) survivors in a human immunodeficiency virus (HIV) prevalent…