Resource Library

The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms. They may be used for vaginal and/or rectal…

June 13, 2019

The Evidence for Contraceptive Options and HIV Outcomes (ECHO) Study is an open-label randomised clinical trial comparing three highly effective, reversible methods of contraception — a progestogen-only injectable called depot-medroxyprogesterone acetate (DMPA), a levonorgestrel implant and the…

The ring introduction matrix is an early-stage implementation tool intended to help policymakers and implementers consider the introduction of the dapivirine ring alongside oral PrEP.

Despite being designed for autonomous use, research suggests partner approval is often necessary in women's microbicide use. Microbicide study participants have described many ways product use affects relationships, from improving sexual pleasure to increasing harm, including exacerbating…

The Southern African HIV Clinicians Society’s biannual conference, held in Johannesburg, South Africa, from 24-27 October 2018, focused on clinical content for HIV and TB health care workers in the region and featured a wide range of topics…

As everyone in the field is aware, the NIH conducted an input process last year that concluded with a release of new HIV prevention research priorities that favor long acting, systemic formulations (like vaccines, implants and injectables) and negate the need for short acting, user-controlled,…

This photo story, about implementing the CHARISMA intervention pilot in Johannesburg, South Africa, illustrates how the pilot unfolded, starting with CHARISMA lay counselors conducting relationship assessments in 2016 with women using the vaginal dapivirine ring for HIV prevention in the MTN-025…

The International Partnership for Microbicides (IPM) 2017 annual report takes a look at promising woman-centered technologies that could expand women's prevention options and help empower them to protect their sexual and reproductive health on their own terms. Available in …

HIV in Mauritius is in a concentrated phase. Most HIV infection is among key populations (KPs) including female sex workers (FSW), people who inject drugs (PWID), men who have sex with men (MSM), and transgender sex workers (TGSW). The objective of this research was to use geographical mapping…

This case study is about the Consortium of MSM and Transgender Networks (the Consortium), a groundbreaking collaboration of global and regional networks by and for men who have sex with men (MSM) and transgender people. It describes the Consortium’s achievements, good practices and lessons…

April 12, 2018

UNAIDS has just relaunched its Key Populations Atlas, an online tool that provides a range of information about members of key populations worldwide, including sex workers, gay men and other men who have sex with men,…

Written in plain terms and organized for quick review, the popular Family Planning: A Global Handbook for Providers offers clinic-based health care professionals in low- and middle-income countries the latest guidance on providing contraceptive methods. Updated to include expanded…

The South African National Aids Council (SANAC) launched South Africa’s first ever LGBTI HIV Plan at a satellite session during this year’s SA AIDS Conference at Durban’s Inkosi Albert Luthuli International Convention Centre.

The LGBTI HIV Plan is a strategic guide…

Sub-Saharan Africa bears more than two-thirds of the worldwide burden of HIV; however, data among transgender women from the region are sparse. Transgender women across the world face significant vulnerability to HIV. This analysis aimed to assess HIV prevalence as well as psychosocial and…

In all countries where there is an HIV epidemic, certain subgroups of the population are at greater risk of HIV than others. These “key” populations include female sex workers (FSWs), men who have sex with men (MSM), transgender people, and people who inject drugs.

While biological and…

To mark the 9th IAS Conference on HIV Science, the Lancet journals have made a selection of content free that reflects some of the breadth and diversity of clinical, epidemiological, and operational HIV research produced by the tireless global HIV community. The content includes…

Topical prevention of HIV and other STIs is a global health priority. To provide options for users, developers have worked to design safe, effective and acceptable vaginal dissolving film formulations. We aimed to characterize user experiences of vaginal film size, texture and color, and their…

Women globally need access to multipurpose prevention technologies (MPTs) that prevent human immunodeficiency virus (HIV), sexually transmitted infections that increase HIV acquisition/transmission risk, and unintended pregnancy. Seeking an MPT with activity against HIV, herpes simplex virus-2 (…

The current cohort of adolescents and young adults (10–24 years) is the largest the world has ever seen, representing an enormous challenge for health systems and health services, particularly in low- and middle-income countries. Unmet need for both sexual and reproductive health and rights (…

The lesbian, gay, bisexual, transgender and intersex (LGBTI) case study was undertaken by the National Population Unit (NPU) to assess the activities that are run by the organisation OUT. This study forms part of 10 such studies with regard to youth which was undertaken by the NPU. The study…

For persons at risk of HIV infection who practice receptive anal intercourse (RAI), topical rectal microbicides represent a promising option for coitally-dependent protection. The study compared colorectal distribution and user sensory experiences of two different volumes of rectal gel for…

Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among African women, the incidence of HIV-1 infection was not reduced, probably because of low adherence. Longer-acting methods of…

Under the Preventive Technologies Agreement supported by the US Agency for International Development, FHI 360 implemented two projects designed to increase understanding of the gender issues likely to affect women’s microbicide use. Findings, including the role of male partners, will inform the…

The Pathways to High Adherence manual was designed for research teams that are involved in supporting adherence to use of antiretroviral-based vaginal rings in HIV prevention clinical trials. Much of the content is also applicable to clinical trials of other HIV prevention products,…

A number of presentations at the 2016 HIV Research for Prevention Conference (HIVR4P) in Chicago looked at the influence vaginal bacteria have on HIV susceptibility, and one presentation found that vaginal bacteria may have profound effects on the…

IPM's 2015 annual report looks at promising new technologies in IPM's pipeline that could put the power of HIV prevention in women's hands. These products include IPM's monthly dapivirine ring – the first microbicide to show efficacy in two Phase III trials – and next-generation products that …

The purpose of Project Gel was to determine the safety and acceptability of rectal microbicides in young men who have sex with men (MSM) and transgender women (TGW) at risk of HIV infection.