Resource Library

The Partnership for HIV-Free Survival (PHFS) was designed to use basic quality improvement practices to reduce mother-to-child transmission of HIV and increase child survival through improvements in (1) antiretroviral therapy uptake and retention among HIV-positive pregnant women and mothers, (2…

The Accelerating Children’s HIV/AIDS Treatment (ACT) Initiative was a public-private partnership that expanded pediatric HIV services in nine sub-Saharan African countries from 2014-2016, providing treatment to more than 560,000 children living with HIV. The ACT Initiative was implemented by…

This first progress report shows that members of the Global HIV Prevention Coalition have mobilized around strengthening HIV primary prevention. There are clear signs of renewed political commitment and strengthened institutional arrangements for planning and managing prevention programmes. Most…

Lesotho's HIV prevalence among pregnant women is 28%. In 2013, Lesotho's Prevention of Mother to Child Transmission (PMTCT) program adopted Option B+ and revitalized the village health worker (VHW) program to strengthen community level PMTCT. The national goal was to test 95% of HIV-exposed…

An essential first step in caring for HIV-infected children is accurate and early diagnosis of HIV, early HIV testing, prompt return of results, and rapid initiation of treatment. Survival of HIV‐infected infants depends on a robust early infant diagnosis (EID) system that allows for tracking of…

Remarkable progress is being made on HIV treatment. Ahead of World AIDS Day, UNAIDS has launched a new report showing that access to treatment has risen significantly. In 2000, just 685 000 people living with HIV had access to antiretroviral therapy. By June 2017, around 20.9 million people had…

This report compiles the latest body of evidence on how stigma and discrimination create barriers across the HIV prevention, testing and treatment cascades and reduce the impact of the AIDS response. The report also brings together best practices on confronting stigma and discrimination,…

This report documents progress on implementation of a Swedish International Development Cooperation Agency (Sida)-funded UNESCO project that aims to strengthen sexuality education programmes for young people in school settings in Zambia. The project was conceptualized in line with the country’s…

The following abstract was presented as part of a poster dicussion session on viral reservoirs at the 9th IAS Conference on HIV Science (IAS 2017).

Background: In the 6-year CHER trial (2005-2011), HIV-infected infants were randomized to deferred antiretroviral therapy (…

Adolescents are unique in their development, their health and their social needs; therefore, their service requirements are different. The developmental changes experienced during adolescence make it one of the most rapidly changing stages of life. These changes impact on adolescents’ health,…

Infants exposed to an antiretroviral regimen of tenofovir, emtricitabine and efavirenz (Atripla) from conception experienced fewer adverse birth outcomes compared to other three-drug regimens, according to a study of births in Botswana between 2014 and 2016, presented on Tuesday at the …

Angola has a generalized, heterosexually-driven HIV epidemic with an adult prevalence of 2.42 percent, according to 2014 estimates from the Joint United Nations Programme on HIV/AIDS (UNAIDS 2014a). The proportion of women receiving ART to prevent mother-to-child transmission (MTCT) of HIV has…

Angola has a generalized, heterosexually-driven HIV epidemic with an adult prevalence of 2.42 percent, according to 2014 estimates from the Joint United Nations Programme on HIV/AIDS (UNAIDS 2014a). The proportion of women receiving ART to prevent mother-to-child transmission (MTCT) of HIV has…

The past decade has seen tremendous progress in making services to prevent mother-to-child transmission of HIV (PMTCT) services more available in many HIV high-prevalence settings. Despite this progress, new HIV infections among pregnant women, newborns, and infants remain unacceptably high, and…

Objective: This prospective study investigated the relationship between male antenatal clinic (ANC) involvement and infant HIV-free survival.

Methods: From 2009 to 2013, HIV-infected pregnant women were enrolled from 6 ANCs in Nairobi,…

Timely access to antiretroviral treatment (ART) is vital to ensuring safe motherhood and reducing vertical transmission. Treatment guidance and programming has changed dramatically in recent years. While progress has been made in improving maternal health, more is needed, including efforts to…

Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk…

Addressing gender norms and inequities is essential to reducing HIV risk, mitigating its impact, and increasing access to services for men and women. The U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) promotes the integration of gender throughout its prevention, care, and treatment…

MANET+, the national coordinating body for community-based support groups in Malawi, was founded in 1997 by a group of PLHIV who recognized the need to organize their activities to achieve greater impact on national HIV policies. This case study analyzes the engagement of CSOs in PMTCT policy…

The number of infants infected with HIV is declining with the rise in interventions for the elimination of paediatric HIV infection, but the number of uninfected infants exposed to HIV through their HIV-infected mothers is increasing. Interest in the health outcomes of HIV-exposed, uninfected…

The U.S. Agency for International Development's (USAID's) 2014 Acting on the Call Report formulated country-specific plans for working with partners in 24 priority countries to save the lives of mothers and children. The follow-up 2015 Acting on the Call Report provided country-by-country…

Since the late 1990s, by providing services to prevent mother-to-child transmission of HIV, many countries have made significant progress toward eliminating new HIV infections in children. The introduction and rollout of Option B+ was a contributing factor in these achievements and an important…

As part of Disease Control Priorities 3rd Edition, the World Bank will publish a volume on Reproductive, Maternal, Newborn, and Child Health that identifies essential cost-effective health interventions that can be scaled up to reduce maternal, newborn, and child deaths, and…

Background:

HIV-infected women risk sexual and perinatal HIV transmission during conception, pregnancy, childbirth, and breastfeeding. We compared HIV-1 RNA suppression and medication adherence across periconception, pregnancy, and postpartum periods, among women on…

This supplement to Acta Paediatrica presents a series of meta-analyses and systematic literature reviews examining a variety of health effects potentially related to breastfeeding. The authors carefully study a wide breadth of the literature to describe current…

This is the fourth annual report of the Global Plan, and it summarizes the progress made through December 2014. The final accountability report of the Global Plan will be…

BACKGROUND:

South Africa (SA) is likely to meet the National Strategic Plan target of

OBJECTIVE: To evaluate the impact of substituting this recommendation for the post-weaning HIV testing recommended by SA guidelines. 

METHODS…

Introduction

Male involvement (MI) is vital for the uptake of Prevention of Mother to Child Transmission (PMTCT) of Human Immunodeficiency Virus (HIV) interventions. Partner notification (PN) is among the strategies identified for MI in PMTCT services. The purpose of this…