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Tenofovir is less toxic than other nucleoside reverse-transcriptase inhibitors used in antiretroviral therapy (ART) and may improve retention of human immunodeficiency virus (HIV)–infected patients on ART. We assessed the impact of national guideline changes in South Africa (2010) and Zambia (…

Stepping Stones is a widely used life skills training intervention focused on curbing gender-based violence (GBV) and reducing HIV risk. But how easy is it to adapt the program to informal settlements—unplanned communities where thousands of people live yet are often…

Background: Retention in care is associated with improved virological control and survival among HIV-infected children. However, retention of children in HIV care remains a challenge.

Objectives: To describe, using routine laboratory HIV test data, the…

How does the endorsement of different dimensions of gender norms by men and/or women influence their use of HIV testing and antiretroviral treatment? This question was examined using data from a 2014 population-based survey of 1053 women and 1004 men, ages 18–49, in rural South Africa. We used a…

Background: An estimated 7.9 million people were living with HIV in South Africa in 2017, with 63.3% of them remaining in antiretroviral therapy (ART) care and 62.9% accessing ART. Poor retention in care and suboptimal adherence to ART undermine the successful efforts of…

INTRODUCTION: Adolescent girls and young women aged 15 to 24 years have some of the highest HIV incidence rates globally, with girls two to four times more likely to be living with HIV than their male peers. High levels of intimate partner…

BACKGROUND: A universal testing and treatment strategy is a potential approach to reduce the incidence of human immunodeficiency virus (HIV)…

BACKGROUND: The NEVEREST-3 (South Africa) and MONOD-ANRS-12206 (Cote d'Ivoire, Burkina Faso) randomized trials found that switching to efavirenz (…

INTRODUCTION: The South African public health system plays an important role in the delivery of HIV testing and treatment services. The health…

There is a need for a culturally adapted, evidence-based, psychotherapy treatment that is effective, acceptable, and feasible for integration into primary care in South Africa. This qualitative study used exit interviews to…

BACKGROUND: Heterosexual men in South Africa are a large key population to exposure to HIV, yet preferences for HIV pre-exposure prophylaxis (PrEP)…

BACKGROUND: Little is known about contextual factors that predict long-term mortality following HIV testing in resource-limited settings. We…

BACKGROUND: Since the introduction of nurse-initiated and managed antiretroviral treatment (NIMART) in South Africa in 2010, initiation of…

BACKGROUND: Gauteng Province has the second lowest tuberculosis (TB) incidence rate in South Africa but the greatest proportion of TB/HIV co-…

There is increasing interest in home-based testing and treatment of HIV to expand access to treatment in sub-Saharan Africa. Such programs rely on self-reported HIV history and use of antiretroviral therapy (ART). However, the accuracy…

The Southern Africa HIV and AIDS Regional Exchange (SHARE) is pleased to present the latest issue of the research digest. The digest offers article abstracts from peer-reviewed literature related to HIV and AIDS in southern Africa and is designed to keep you in touch with the rapidly expanding…

BACKGROUND: Women account for 56% of new HIV infections in sub-Saharan Africa. Multipurpose Prevention Technologies (MPTs) are promising interventions because they combine HIV prevention with a less stigmatizing indication, such as pregnancy…

BACKGROUND: The Human Immunodeficiency Virus (HIV) epidemic is growing rapidly among South African adolescents and young adults (AYA). Although HIV counselling and testing, HIV prevention and treatment options are widely available, many AYA…

BACKGROUND: Additional approaches are needed to identify and provide targeted interventions to populations at continued risk for HIV-associated mortality. We sought to describe care utilization and mortality following an index hospitalization…

SOAR researchers assessed a community-based program that provided female sex workers with mobile or home-based ART services. The findings demonstrate that the community-based model can lead to higher ART initiation and retention rates, and better adherence compared to standard…

Background: The Eastern Cape province of South Africa has one of the highest burdens of HIV in the world. Emergency Departments (EDs) can serve as optimal clinical sites for the identification of new HIV infections and entry into care. We sought to determine the current burden…

mothers2mothers (m2m) is an African NGO working towards the Global Goals of ensuring good health for all and ending the AIDS epidemic by 2030. The organization focuses on three core client groups—women, children, and adolescents—serving those living with HIV, and also those who are HIV-negative…

The Southern Africa HIV and AIDS Regional Exchange (SHARE) is pleased to present our 9th issue of the research digest. The digest offers article abstracts from peer-reviewed literature related to HIV and AIDS in southern Africa and is designed to keep you in touch with the rapidly expanding…

BACKGROUND: Sub-Saharan African correctional facilities concentrate large numbers of people who are living with HIV or at risk for HIV infection. Universal test and treat (UTT) is widely recognized as a promising approach to improve the health of individuals and a population…

BACKGROUND: The Sub-Saharan Africa region still remains the epicentre of the global HIV/AIDS epidemic. With regards to new paediatric HIV infections, almost 90% of new HIV infections are among children (aged 0-14 years), largely through mother to child transmission. Male Partner…

BACKGROUND: Expanded HIV prevention options are needed to increase uptake of HIV prevention among women, especially in generalized epidemics. As the dapivirine vaginal ring moves forward through regulatory review and open-label extension studies, the potential public health…

Background: Observational and laboratory studies suggest that some hormonal contraceptive methods, particularly intramuscular depot medroxyprogesterone acetate (DMPA-IM), might increase women's susceptibility to HIV acquisition. We aimed to compare DMPA-IM, a copper intrauterine…

This report documents the results of a baseline assessment carried out in South Africa to support its efforts to scale up programs to reduce human-rights-related barriers to HIV and TB services. Since the adoption of its new Strategy 2017-2022: Investing to End Epidemics, the Global Fund has…