Resource Library

Introduction

Few studies have systematically described population‐level differences comparing men and women across the continuum of routine HIV care. This study quantifies differentials in HIV care, treatment and mortality outcomes for men and women over…

Background

HIV diagnosis is a critical step in linking HIV-infected individuals to care and treatment and linking HIV-uninfected persons to prevention services. However, the uptake of HIV testing remains low in many countries. HIV self-screening (HIVSS) is acceptable to…

Background: The World Health Organization recommends "same-day" initiation of antiretroviral therapy (ART) for HIV patients who are eligible and ready. Identifying efficient, safe, and feasible procedures for determining same-day eligibility and readiness is now a priority. The…

Tenofovir is less toxic than other nucleoside reverse-transcriptase inhibitors used in antiretroviral therapy (ART) and may improve retention of human immunodeficiency virus (HIV)–infected patients on ART. We assessed the impact of national guideline changes in South Africa (2010) and Zambia (…

Background: An estimated 7.9 million people were living with HIV in South Africa in 2017, with 63.3% of them remaining in antiretroviral therapy (ART) care and 62.9% accessing ART. Poor retention in care and suboptimal adherence to ART undermine the successful efforts of…

There is a need for a culturally adapted, evidence-based, psychotherapy treatment that is effective, acceptable, and feasible for integration into primary care in South Africa. This qualitative study used exit interviews to…

Background: The Eastern Cape province of South Africa has one of the highest burdens of HIV in the world. Emergency Departments (EDs) can serve as optimal clinical sites for the identification of new HIV infections and entry into care. We sought to determine the current burden…

mothers2mothers (m2m) is an African NGO working towards the Global Goals of ensuring good health for all and ending the AIDS epidemic by 2030. The organization focuses on three core client groups—women, children, and adolescents—serving those living with HIV, and also those who are HIV-negative…

BACKGROUND: Many adolescents living with HIV remain disconnected from care, especially in high-prevalence settings. Slow progressors-adolescents infected perinatally who survive without access to lifesaving treatment-remain unidentified and disconnected from heath systems,…

BACKGROUND: Antiretroviral adherence is vital to the successful long-term rollout of the antiretroviral therapy program in South Africa. At present, there are no studies that look at the effects of disability on antiretroviral adherence.

METHODS: Drawing…

There is evidence of increasing levels of pretreatment HIV drug resistance (PDR) in Southern Africa. We used data from two large population-based HIV surveillance studies to estimate prevalence of PDR in KwaZulu-Natal, the province with the highest HIV prevalence in South Africa. Sanger…

Community-based HIV testing and counseling (HTC) programs have become an important part of the healthcare system in South Africa and other low- and middle-income countries with a high HIV prevalence and strained primary healthcare system. Current HTC programs excel at identifying people living…

BACKGROUND: Although empirical evidence suggests that the adherence club model is more effective in retaining people living with HIV in antiretroviral treatment care and sustaining medication adherence compared to standard clinic care, it is poorly understood exactly how and why…

Objective: To study retention in care (RIC) trajectories and associated factors in patients eligible for antiretroviral therapy (ART) in a universal test-and-treat setting (TasP trial, South Africa, 2012–2016).

Design: A cluster-randomized trial whereby…

We assessed the relationship between distance to clinic and progression through the HIV care cascade. We have two key findings. First, distance matters but only for women. Second, for women, distance affected linkage to care, but was not associated with later transitions in the care cascade. It…

Background: Depression is a leading cause of disability and may be associated with decreased adherence to ART. We sought to describe the prevalence of depressive symptoms and outcomes one year after screening among patients receiving ART at a large HIV Clinic in Johannesburg,…

Professor Quarraisha Abdool Karim is one of the world’s leading AIDS researchers and has made pioneering contributions to understanding the HIV epidemic in young people, especially among young women. She joined us for a two-part series to explain her latest research into epidemic hot spots in…

The Partnership for HIV-Free Survival (PHFS) was designed to use basic quality improvement practices to reduce mother-to-child transmission of HIV and increase child survival through improvements in (1) antiretroviral therapy uptake and retention among HIV-positive pregnant women and mothers, (2…

Across sub-Saharan Africa, prevention of mother-to-child transmission services are encountering increasing numbers of women already established on antiretroviral therapy (ART) when entering antenatal care. However…

Background

Initiation of antiretroviral therapy (ART) following diagnosis of HIV infection at birth is an emerging area of paediatric HIV care. We present outcomes of HIV-infected infants identified at birth at Rahima Moosa Mother and Child Hospital in Johannesburg,…

Ukuba sempilweni lilungelo lethu singabantu. Zininzi izinto esingazenza singabantu kwakunye nabahlali ukuzigcina sisempilweni kangangoko. Oku kuya kuqinisekisa ukuba singakwazi ukuphila impilo ende enolonwabo kwaye sinakekele abo sibathandayo.

Izifo ezifana neHIV ne-AIDS, isifo sephepha…

Ukuba nempilo kuyilungelo lethu njengabantu. Kunezinto eziningi esingazenza njengabantu ngabodwana kanye nemiphakathi ukuze sihlale siphile ngendlela esingakwazi ukuthi senze ngayo. Lokhu kuzoqinisekisa ukuthi singakwazi ukuphila impilo ende futhi enentokozo nokuthi singakwazi ukunakekela…

This volume of Health Systems Trust’s 90-90-90 Compendium offers a handy resource for community health workers and caregivers, community-based and faith-based organisations, and other networked associations, to share with community members about their role in combating the HIV epidemic.

This volume of Health Systems Trust’s 90-90-90 Compendium offers a handy resource for community health workers and caregivers, community-based and faith-based organisations, and other networked associations, to share with community members about good health and staying healthy with chronic…

The purpose of this guide is to provide a resource for clinicians on the ground who manage HIV and TB clients on a daily basis. The guide presents the tools and knowledge required to ensure that clients are offered the best quality of service, and will also enable the health facility to move…

This first volume of the 90-90-90 Compendium is targeted at a wide range of readers in South Africa, including community members and/or politicians with no medical background. It is designed to assist all health sector role-players in understanding the context of the 90-90-90 strategy, as…

South Africa has implemented a community-based HIV programme (CBHP) in its primary healthcare (PHC) re-engineering strategy that aims to improve public healthcare delivery. This CBHP is delivered by ward-based outreach teams (WBOTs); provision of community HIV services comprises an important…

BACKGROUND: HPTN071 (PopART) is a 3-arm community-randomised study in 21 peri-urban/urban communities in Zambia and the Western Cape of South…