Resource

Towards more accurate HIV testing in sub-Saharan Africa: a multi-site evaluation of HIV RDTs and risk factors for false positives

10 April 2017 by SHARE Administrator
Resource details
2017
Cara S Kosack, Anne-Laure Page, Greet Beelaert, Tumwesigye Benson, Aboubacar Savane, Anne Ng’ang’a, Bita Andre, Jean-Paul BN Zahinda, Leslie Shanks, Katrien Fransen

Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues. Despite widespread use of RDTs for HIV diagnosis in resource-constrained settings, there has been no systematic, head-to-head evaluation of their accuracy with specimens from diverse settings across sub-Saharan Africa. We conducted a standardized, centralized evaluation of eight HIV RDTs and two simple confirmatory assays at a WHO collaborating centre for evaluation of HIV diagnostics using specimens from six sites in five sub-Saharan African countries.